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Cerebral malaria dissertation

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Celebral Malaria is the most important course of P. The clinical criteria consist of unarousable coma, exclusion of other encephalopathies and the confirmation of P. Frequently other organs are involved parallel dysfunction. The golden standard of therapy for severe P.
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Dissertation Defense – Yue Song

Cerebral malaria dissertation
Cerebral malaria dissertation
Cerebral malaria dissertation
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"The Role of Histidine Rich Protein II in Cerebral Malaria" by Priya Pal

As a result, iron deficiency ID , which is the most common nutritional disorder in the world, is associated with a variety of functional deficits that can result in long-term neurological impairments. The focus of my thesis is the iron storage protein ferritin and its receptor Tim2 T cell immunoglobulin and mucin domain containing 2. The Tim2 receptor is expressed by oligodendrocytes in the brain and the interaction between ferritin and the Tim2 receptor is important for iron delivery and differentiation. The thesis begins with an overview of iron homeostasis. In addition to ferritin, Tim2 also interacts with Semaphorin4A Sema4A , which has been implicated as a cytotoxic agent for oligodendrocytes in multiple sclerosis. We investigated the effect of Sema4A on oligodendrocytes in Chapter 3 and also in a model of neuroinflammatory disease known to have myelin damage, cerebral malaria CM. Our findings give insight into the pathogenesis of CM under varying conditions of iron dyshomeostasis and provide implications for therapeutic strategies in treating ID and CM.
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What is Cerebral Malaria & How is it Treated?

Priya Pal , Washington University in St. Louis Follow. Human malaria is caused by five species of Plasmodium.
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Malaria , serious relapsing infection in humans, characterized by periodic attacks of chills and fever, anemia , splenomegaly enlargement of the spleen , and often fatal complications. It is caused by one-celled parasites of the genus Plasmodium that are transmitted to humans by the bite of Anopheles mosquitoes. Malaria can occur in temperate regions, but it is most common in the tropics and subtropics.
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